Integrating In Vitro Dissolution and Physiologically Based Pharmacokinetic Modeling for Generic Drug Development: Evaluation of Amorphous Solid Dispersion Formulations for Tacrolimus

Integrating In Vitro Dissolution and Physiologically Based Pharmacokinetic Modeling for Generic Drug Development: Evaluation of Amorphous Solid Dispersion Formulations for Tacrolimus

<b>Objectives</b>: Tacrolimus, a Biopharmaceutics Classification System (BCS) class II drug, is widely used for transplant patients to prevent graft rejection. To enhance its bioavailability, amorphous solid dispersion (ASD) formulations were developed and evaluated. The release properti...

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Autors principals: Evangelos Karakitsios, Maria-Faidra-Galini Angelerou, Iasonas Kapralos, Georgia Tsakiridou, Lida Kalantzi, Aristides Dokoumetzidis
Format: Article
Idioma:English
Publicat: MDPI AG 2025-02-01
Col·lecció:Pharmaceutics
Matèries:
physiologically based biopharmaceutics model
amorphous solid dispersion
biorelevant dissolution test
Accés en línia:https://www.mdpi.com/1999-4923/17/2/227

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https://www.mdpi.com/1999-4923/17/2/227

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