Integrating In Vitro Dissolution and Physiologically Based Pharmacokinetic Modeling for Generic Drug Development: Evaluation of Amorphous Solid Dispersion Formulations for Tacrolimus

Integrating In Vitro Dissolution and Physiologically Based Pharmacokinetic Modeling for Generic Drug Development: Evaluation of Amorphous Solid Dispersion Formulations for Tacrolimus

<b>Objectives</b>: Tacrolimus, a Biopharmaceutics Classification System (BCS) class II drug, is widely used for transplant patients to prevent graft rejection. To enhance its bioavailability, amorphous solid dispersion (ASD) formulations were developed and evaluated. The release properti...

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Bibliographic Details
Main Authors: Evangelos Karakitsios, Maria-Faidra-Galini Angelerou, Iasonas Kapralos, Georgia Tsakiridou, Lida Kalantzi, Aristides Dokoumetzidis
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceutics
Subjects:
physiologically based biopharmaceutics model
amorphous solid dispersion
biorelevant dissolution test
Online Access:https://www.mdpi.com/1999-4923/17/2/227

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https://www.mdpi.com/1999-4923/17/2/227

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