Multi-view graph convolutional network for cancer cell-specific synthetic lethality prediction

Synthetic lethal (SL) genetic interactions have been regarded as a promising focus for investigating potential targeted therapeutics to tackle cancer. However, the costly investment of time and labor associated with wet-lab experimental screenings to discover potential SL relationships motivates the...

Full description

Bibliographic Details
Main Authors: Kunjie Fan, Shan Tang, Birkan Gökbağ, Lijun Cheng, Lang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1103092/full