Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis.

Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis.

BACKGROUND: Microalbuminuria is an early lesion during the development of diabetic nephropathy. The loss of high molecular weight proteins in the urine is usually associated with decreased expression of slit diaphragm proteins. Nephrin, is the major component of the glomerular slit diaphragm and los...

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Bibliographic Details
Main Authors: Irini Tossidou, Beina Teng, Jan Menne, Nelli Shushakova, Joon-Keun Park, Jan U Becker, Friedrich Modde, Michael Leitges, Hermann Haller, Mario Schiffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2855708?pdf=render

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http://europepmc.org/articles/PMC2855708?pdf=render

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