Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency

Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency

Background: The blood-nerve and myelin barrier shield peripheral neurons and their axons. These barriers are sealed by tight junction proteins, which control the passage of potentially noxious molecules including proinflammatory cytokines via paracellular pathways. Peripheral nerve barrier breakdown...

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Bibliographic Details
Main Authors: Jeremy Tsung-Chieh Chen, Xiawei Hu, Isabel U.C. Otto, Christina Schürger, Bruno Rogalla von Bieberstein, Kathrin Doppler, Susanne M. Krug, Mohammed K. Hankir, Rosel Blasig, Claudia Sommer, Alexander Brack, Ingolf E. Blasig, Heike L. Rittner
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Neurobiology of Disease
Subjects:
Pain
Neuropathy
Blood-nerve barrier
Tight junction protein
Myelin barrier
Sonic hedgehog
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002619

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http://www.sciencedirect.com/science/article/pii/S0969996123002619

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