A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate

A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate

Salivary glands are vital structures responsible for successful tick feeding. The saliva of ticks contains numerous active molecules that participate in several physiological processes. A Kunitz-type factor Xa (FXa) inhibitor, similar to the tissue factor pathway inhibitor (TFPI) precursor, was iden...

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Bibliographic Details
Main Authors: Aline R. M. Lobba, Miryam Paola Alvarez-Flores, Melissa Regina Fessel, Marcus Vinicius Buri, Douglas S. Oliveira, Renata N. Gomes, Priscila S. Cunegundes, Carlos DeOcesano-Pereira, Victor D. Cinel, Ana M. Chudzinski-Tavassi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
amblyomin-X
proteasome inhibitor
TFPI-like
antitumor / cytotoxic activity
bioactive molecule
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.936107/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.936107/full

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