Chelator PBT2 Forms a Ternary Cu<sup>2+</sup> Complex with β-Amyloid That Has High Stability but Low Specificity
The metal chelator PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) acts as a terdentate ligand capable of forming binary and ternary Cu<sup>2+</sup> complexes. It was clinically trialed as an Alzheimer’s disease (AD) therapy but failed to progress beyond phase II. The β-...
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Format: | Article |
Language: | English |
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MDPI AG
2023-05-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/24/11/9267 |