Chelator PBT2 Forms a Ternary Cu<sup>2+</sup> Complex with β-Amyloid That Has High Stability but Low Specificity

Chelator PBT2 Forms a Ternary Cu<sup>2+</sup> Complex with β-Amyloid That Has High Stability but Low Specificity

The metal chelator PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) acts as a terdentate ligand capable of forming binary and ternary Cu<sup>2+</sup> complexes. It was clinically trialed as an Alzheimer’s disease (AD) therapy but failed to progress beyond phase II. The β-...

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Bibliographic Details
Main Author:	Simon C. Drew
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Series:	International Journal of Molecular Sciences
Subjects:	8-hydroxyquinoline PBT2 amyloid copper ternary terdentate
Online Access:	https://www.mdpi.com/1422-0067/24/11/9267

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