Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

ABSTRACTAntibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from free IgG in solution and have equivalent affinities f...

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Bibliographic Details
Main Authors: Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis, Margaret E. Ackerman
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Affinity
allostery
antibody
Fc receptor
immunoglobulin G
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2231128

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2231128

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