Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

ABSTRACTAntibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from free IgG in solution and have equivalent affinities f...

Descrizione completa

Dettagli Bibliografici
Autori principali: Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis, Margaret E. Ackerman
Natura: Articolo
Lingua:English
Pubblicazione: Taylor & Francis Group 2023-12-01
Serie:mAbs
Soggetti:
Affinity
allostery
antibody
Fc receptor
immunoglobulin G
Accesso online:https://www.tandfonline.com/doi/10.1080/19420862.2023.2231128

Accesso online

https://www.tandfonline.com/doi/10.1080/19420862.2023.2231128

Documenti analoghi