Hepatic transcript signatures predict atherosclerotic lesion burden prior to a 2-year high cholesterol, high fat diet challenge.

Hepatic transcript signatures predict atherosclerotic lesion burden prior to a 2-year high cholesterol, high fat diet challenge.

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The purpose of this study was to identify molecular mechanisms by which the liver influences total lesion burden in a nonhuman primate model (NHP) of cardiovascular disease with acute and chronic feeding of a high cholesterol, high fat (HCHF) diet. Baboons (47 females, 64 males) were fed a HCHF diet...

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Bibliographic Details
Main Authors: Sobha Puppala, Kimberly D Spradling-Reeves, Jeannie Chan, Shifra Birnbaum, Deborah E Newman, Anthony G Comuzzie, Michael C Mahaney, John L VandeBerg, Michael Olivier, Laura A Cox
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0271514

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https://doi.org/10.1371/journal.pone.0271514

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