Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL[S]
HDL-associated paraoxonase 1 (PON1) activity is associated with cardiovascular and other human diseases. As the role of genetic variants outside of the PON gene cluster on PON1 activity is unknown, we sought to identify common and rare variants in such loci. We typed 33,057 variants on the CVD chip...
Main Authors: | Daniel S. Kim, Amber A. Burt, David R. Crosslin, Peggy D. Robertson, Jane E. Ranchalis, Edward J. Boyko, Deborah A. Nickerson, Clement E. Furlong, Gail P. Jarvik |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2013-02-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520428202 |
Similar Items
-
Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project[S]
by: Daniel Seung Kim, et al.
Published: (2014-06-01) -
Phenome Wide Association Studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index
by: Robert Michael Cronin, et al.
Published: (2014-08-01) -
Dietary cholesterol increases paraoxonase 1 enzyme activity
by: Daniel S. Kim, et al.
Published: (2012-11-01) -
The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status
by: Laura S. Rozek, et al.
Published: (2005-09-01) -
Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol[S]
by: Daniel S. Kim, et al.
Published: (2013-05-01)