Molecular dynamic simulation, free binding energy calculation of Thiazolo-[2,3-b]quinazolinone derivatives against EGFR-TKD and their anticancer activity
Epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD) plays a crucial role in the onset and progression of different types of cancers. The existing EGFR-TKD inhibitors have many adverse side effects, which make them unsuitable to be used as cancer therapeutics. This study aims to design...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622001370 |