Prior viral infection primes cross-reactive CD8+ T cells that respond to mouse heart allografts

Prior viral infection primes cross-reactive CD8+ T cells that respond to mouse heart allografts

IntroductionSignificant evidence suggests a connection between transplant rejection and the presence of high levels of pre-existing memory T cells. Viral infection can elicit viral-specific memory T cells that cross-react with allo-MHC capable of driving allograft rejection in mice. Despite these ad...

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Bibliographic Details
Main Authors: M. Eyad Khorki, Tiffany Shi, Eileen E. Cianciolo, Ashley R. Burg, P. Chukwunalu Chukwuma, Jennifer L. Picarsic, Mary K. Morrice, E. Steve Woodle, Jonathan S. Maltzman, Autumn Ferguson, Jonathan D. Katz, Brian M. Baker, David A. Hildeman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
transplant
cross-reactivity
TCR (T cell receptor)
LCMV (lymphocytic choriomeningitis virus)
transplantation
CD8+ T cell response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1287546/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1287546/full

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