Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms.

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms.

Glucose and palmitate synergistically stimulate insulin secretion, but chronically elevated they induce apoptotic β-cell death. The glucotoxic effect has been attributed, at least partly, to the upregulation of the oxidative stress marker thioredoxin interacting protein (TXNIP). Palmitate downregula...

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Bibliographic Details
Main Authors: Madhura Panse, Oliver Kluth, Estela Lorza-Gil, Gabriele Kaiser, Eckhard Mühlbauer, Annette Schürmann, Hans-Ulrich Häring, Susanne Ullrich, Felicia Gerst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5973613?pdf=render

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http://europepmc.org/articles/PMC5973613?pdf=render

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