Synthesis and cloning of long repeat sequences using single-stranded circular DNA

Synthesis and cloning of long repeat sequences using single-stranded circular DNA

Non-coding repeat expansion causes several neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis/frontotemporal dementia, and spinocerebellar ataxia (SCA31). Such repetitive sequences must be investigated to understand disease mechanisms and prevent them, using novel...

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Bibliographic Details
Main Authors: Afsana Bhuiyan, Shuichi Asakawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
repeat sequence
cell-free synthetic biology
in vitro cloning
neurodegenerative diseasaes
spinocerebellar ataxia (SCA) 31
benign adult familial myoclonic epilepsy (BAFME)
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1115159/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1115159/full

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