Safety verification for polysorbate 20, pharmaceutical excipient for intramuscular administration, in Sprague-Dawley rats and New Zealand White rabbits.

Human serum albumin (HSA) has been widely used as a pharmaceutical excipient in Botulinum toxin serotype A (BoNT/A) products that are indicated for use in therapeutics and cosmetics. However, HSA as a human-derived material has some concerns, such as the potential risk of transmission of infectious...

Full description

Bibliographic Details
Main Authors: Junhyung Kim, Seongsung Kwak, Mi-Sun Park, Chang-Hoon Rhee, Gi-Hyeok Yang, Jangmi Lee, Woo-Chan Son, Won-Ho Kang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0256869