Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3

Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3

Abstract Nonalcoholic fatty liver disease (NAFLD) is associated with increased oxidative stress that leads to hepatocyte and mitochondrial damage. In this study we investigated the mechanisms involved in the induction of oxidative stress and impairment of mitochondrial quality control and mitophagy...

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Bibliographic Details
Main Authors: Simon Musyoka Mwangi, Ge Li, Arun Balasubramaniam, Didier Merlin, Paul A. Dawson, Young C. Jang, C. Michael Hart, Mark J. Czaja, Shanthi Srinivasan
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20101-1

Internet

https://doi.org/10.1038/s41598-022-20101-1

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