Functionalizing Collagen with Vessel‐Penetrating Two‐Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia

Functionalizing Collagen with Vessel‐Penetrating Two‐Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia

Abstract The encapsulation and/or surface modification can stabilize and protect the phosphorescence bio‐probes but impede their intravenous delivery across biological barriers. Here, a new class of biocompatible rhenium (ReI) diimine carbonyl complexes is developed, which can efficaciously permeate...

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Bibliographic Details
Main Authors: Cheng‐Ham Wu, Kristina S. Kisel, Muthu Kumar Thangavel, Yi‐Ting Chen, Kai‐Hsin Chang, Ming‐Rung Tsai, Chia‐Yu Chu, Yu‐Fang Shen, Pei‐Chun Wu, Zhiming Zhang, Tzu‐Ming Liu, Janne Jänis, Elena V. Grachova, Julia R. Shakirova, Sergey P. Tunik, Igor O. Koshevoy, Pi‐Tai Chou
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Advanced Science
Subjects:
phosphorescence lifetime imaging microscopy
phosphorescent oxygen sensors
ReI diimine carbonyl complexes
tissue ischemia
tumor hypoxia
two‐photon phosphorescence
Online Access:https://doi.org/10.1002/advs.202102788

Internet

https://doi.org/10.1002/advs.202102788

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