Syzygium zeylanicum (L.) DC. polyphenols exhibit anti-diabetic activity by modulation of ACC1, SGLT1, and GLP-1 genes and restoration of gut microbiota in overfeeding and high glucose exposure-induced diabetic zebrafish

Syzygium zeylanicum (L.) DC. polyphenols exhibit anti-diabetic activity by modulation of ACC1, SGLT1, and GLP-1 genes and restoration of gut microbiota in overfeeding and high glucose exposure-induced diabetic zebrafish

Syzygium zeylanicum (L.) DC. (SZL) has long been used as a traditional remedy for diabetes, but its underlying mechanisms of action remain unknown. This study aimed to investigate the antidiabetic activity of SZL polyphenols (SZL_EAF) via anti-hyperglycemic effect, regulation of gene expression rela...

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Bibliographic Details
Main Authors: Minh-Trung Nguyen, Thi-Bich-Huyen Bui, Van-Hung Pham, Minh-Dinh Tran, Quang-Vinh Nguyen
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Functional Foods
Subjects:
Syzygium zeylanicum (L.) DC
Anti-diabetic activities
Zebrafish gut microbiome
Acetyl-CoA carboxylase 1 (ACC1)
Sodium–glucose cotransporters (SGLT1)
Glucagon-like peptide-1 (GLP-1)
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623005212

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http://www.sciencedirect.com/science/article/pii/S1756464623005212

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