Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway

Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway

Abstract Background Cholesterol (CHO) is an essential component of the body. However, high CHO levels in the body can damage bone mass and promote osteoporosis. CHO accumulation can cause osteoblast apoptosis, which has a negative effect on bone formation. The pathogenesis of osteoporosis is a compl...

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Bibliographic Details
Main Authors: Mingliang Zhong, Zhenyu Wu, Zhixi Chen, Longhuo Wu, Jianguo Zhou
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoporosis
Endoplasmic reticulum stress
Cholesterol
Geniposide
GLP-1R
ABCA1
Online Access:https://doi.org/10.1186/s13018-024-04665-4

Internet

https://doi.org/10.1186/s13018-024-04665-4

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