The Autism Spectrum Disorder-Associated Bacterial Metabolite <i>p</i>-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10

The Autism Spectrum Disorder-Associated Bacterial Metabolite <i>p</i>-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10

The bacterial metabolite 4-methylphenol (<i>para</i>-cresol or <i>p</i>-cresol) and its derivative <i>p</i>-cresyl sulfate (<i>p</i>CS) are elevated in the urine and feces of children with autism spectrum disorder (ASD). It has been shown that <i>...

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Bibliographic Details
Main Authors: Yuanpeng Zheng, Naika Z. Prince, Lucia N. Peralta Marzal, Sabbir Ahmed, Johan Garssen, Paula Perez Pardo, Aletta D. Kraneveld
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
autism spectrum disorder
valproic acid
<i>p-</i>cresol
<i>p-</i>cresyl sulfate
ADAM10
ADAM17
Online Access:https://www.mdpi.com/1422-0067/23/19/11013

Internet

https://www.mdpi.com/1422-0067/23/19/11013

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