Investigation of the role of the miR17-92 cluster in BMP9-induced osteoblast lineage commitment

Abstract Background Bone morphogenetic protein 9 (BMP9) has been identified as a crucial inducer of osteoblastic differentiation in mesenchymal stem cells (MSCs). Although microRNAs (miRNAs) are known to play a role in MSC osteogenesis, the mechanisms of action of miRNAs in BMP9-induced osteoblastic...

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Bibliographic Details
Main Authors: Yunyuan Zhang, Xuran Jing, Zhongzhu Li, Qingwu Tian, Qing Wang, Xian Chen
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-021-02804-9