A Gene Cluster That Encodes Histone Deacetylase Inhibitors Contributes to Bacterial Persistence and Antibiotic Tolerance in Burkholderia thailandensis

A Gene Cluster That Encodes Histone Deacetylase Inhibitors Contributes to Bacterial Persistence and Antibiotic Tolerance in Burkholderia thailandensis

ABSTRACT Persister cells are genetically identical variants in a bacterial population that have phenotypically modified their physiology to survive environmental stress. In bacterial pathogens, persisters are able to survive antibiotic treatment and reinfect patients in a frustrating cycle of chroni...

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Bibliographic Details
Main Authors: Sofiya N. Micheva-Viteva, Migun Shakya, Samantha H. Adikari, Cheryl D. Gleasner, Nileena Velappan, Judith R. Mourant, Patrick S. G. Chain, Elizabeth Hong-Geller
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mSystems
Subjects:
Burkholderia
antibiotic resistance
bacterial persistence
stress
transcriptomics
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00609-19

Internet

https://journals.asm.org/doi/10.1128/mSystems.00609-19

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