Development of a Monoclonal scFv against Cytotoxin to Neutralize Cytolytic Activity Induced by <i>Naja atra</i> Venom on Myoblast C2C12 Cells

Development of a Monoclonal scFv against Cytotoxin to Neutralize Cytolytic Activity Induced by <i>Naja atra</i> Venom on Myoblast C2C12 Cells

The Taiwanese cobra, <i>Naja atra</i>, is a clinically significant species of snake observed in the wild in Taiwan. Victims bitten by <i>N. atra</i> usually experience severe pain and local tissue necrosis. Although antivenom is available for treatment of cobra envenomation,...

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Bibliographic Details
Main Authors: Chien-Chun Liu, Cho-Ju Wu, Tsai-Ying Chou, Geng-Wang Liaw, Yung-Chin Hsiao, Lichieh-Julie Chu, Chi-Hsin Lee, Po-Jung Wang, Cheng-Hsien Hsieh, Chun-Kuei Chen, Jau-Song Yu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Toxins
Subjects:
cobra venom
<i>Naja atra</i>
cytotoxin (CTX)
cytotoxicity
necrosis
single-chain variable fragment (scFv)
Online Access:https://www.mdpi.com/2072-6651/14/7/459

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https://www.mdpi.com/2072-6651/14/7/459

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