Loss of proteostatic control as a substrate for Atrial Fibrillation; a novel target for upstream therapy by Heat Shock Proteins

Loss of proteostatic control as a substrate for Atrial Fibrillation; a novel target for upstream therapy by Heat Shock Proteins

Atrial Fibrillation (AF) is the most common, sustained clinical tachyarrhythmia associated with significant morbidity and mortality. AF is a persistent condition with progressive structural remodeling of the atrial cardiomyocytes due to the AF itself, resulting in cellular changes commonly observed...

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Bibliographic Details
Main Authors: Roelien Amanda Marjolein Meijering, Deli eZhang, Femke eHoogstra-Berends, Robert eHenning, Bianca eBrundel
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Physiology
Subjects:
Calpain
remodeling
AF
geranylgeranylacetone
HSP
myolysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00036/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00036/full

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