Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters responsible for cytoplasmic pH homeostasis. Here, we d...

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Bibliographic Details
Main Authors: Paul G DeCaen, Yuka Takahashi, Terry A Krulwich, Masahiro Ito, David E Clapham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
ion selectivity
bacteria physiology
pharmacology
biochemical adaptation
evolution
antibiotic
Online Access:https://elifesciences.org/articles/04387

Internet

https://elifesciences.org/articles/04387

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