The Acute Radiation Syndrome-Mitigator Romiplostim and Secreted Extracellular Vesicles Improved Survival in Mice Acutely Exposed to Myelosuppressive Doses of Ionizing Radiation

The Acute Radiation Syndrome-Mitigator Romiplostim and Secreted Extracellular Vesicles Improved Survival in Mice Acutely Exposed to Myelosuppressive Doses of Ionizing Radiation

In cases of accidental high-dose total-body irradiation (TBI), acute radiation syndrome (ARS) can cause death. We reported that the thrombopoietin receptor agonist romiplostim (RP) has the potential to completely rescue mice exposed to lethal TBI. Extracellular vesicles (EVs) are involved in cell-to...

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Bibliographic Details
Main Authors: Masaru Yamaguchi, Ikuo Kashiwakura
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomolecules
Subjects:
romiplostim
extracellular vesicles
hematopoietic acute radiation syndrome
radiological or nuclear public health emergency
microRNA
Online Access:https://www.mdpi.com/2218-273X/13/5/837

Internet

https://www.mdpi.com/2218-273X/13/5/837

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