Alpha herpesvirus exocytosis from neuron cell bodies uses constitutive secretory mechanisms, and egress and spread from axons is independent of neuronal firing activity.

Alpha herpesvirus exocytosis from neuron cell bodies uses constitutive secretory mechanisms, and egress and spread from axons is independent of neuronal firing activity.

Alpha herpesviruses naturally infect the peripheral nervous system, and can spread to the central nervous system, causing severe debilitating or deadly disease. Because alpha herpesviruses spread along synaptic circuits, and infected neurons exhibit altered electrophysiology and increased spontaneou...

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Bibliographic Details
Main Authors: Anthony E Ambrosini, Kayla M Borg, Nikhil Deshmukh, Michael J Berry, Lynn W Enquist, Ian B Hogue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-04-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012139&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012139&type=printable

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