The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets

The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets

The cell cycle is controlled by microtubule-associated serine/threonine kinase-like (MASTL), which phosphorylates the cAMP-regulated phosphoproteins 19 (ARPP19) at S62 and 19e/α-endosulfine (ENSA) at S67and converts them into protein phosphatase 2A (PP2A) inhibitors. Based on initial proteo...

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Bibliographic Details
Main Authors: Elena J. Kumm, Oliver Pagel, Stepan Gambaryan, Ulrich Walter, René P. Zahedi, Albert Smolenski, Kerstin Jurk
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
platelets
serine/threonine protein phosphatases
cyclic amp
cyclic gmp
ensa
arpp19
map kinase
Online Access:https://www.mdpi.com/2073-4409/9/2/472

Internet

https://www.mdpi.com/2073-4409/9/2/472

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