Membrane Cholesterol Is Crucial for Clostridium difficile Surface Layer Protein Binding and Triggering Inflammasome Activation

Membrane Cholesterol Is Crucial for Clostridium difficile Surface Layer Protein Binding and Triggering Inflammasome Activation

Clostridium difficile, an obligate anaerobic gram-positive bacillus, generates spores and is commonly found colonizing the human gut. Patients with C. difficile infection (CDI) often exhibit clinical manifestations of pseudomembranous colitis or antibiotic-associated diarrhea. Surface layer proteins...

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Bibliographic Details
Main Authors: Yu Chen, Kai Huang, Liang-Kuei Chen, Hui-Yu Wu, Chih-Yu Hsu, Yau-Sheng Tsai, Wen-Chien Ko, Pei-Jane Tsai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
Clostridium difficile
membrane cholesterol
lipid rafts
surface layer proteins
inflammasome activation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01675/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01675/full

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