Co-Delivery of Novel Synthetic TLR4 and TLR7/8 Ligands Adsorbed to Aluminum Salts Promotes Th1-Mediated Immunity against Poorly Immunogenic SARS-CoV-2 RBD

Co-Delivery of Novel Synthetic TLR4 and TLR7/8 Ligands Adsorbed to Aluminum Salts Promotes Th1-Mediated Immunity against Poorly Immunogenic SARS-CoV-2 RBD

Despite the availability of effective vaccines against COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide, pressing the need for new vaccines with improved breadth and durability. We developed an adjuvanted subunit vaccine against SARS-CoV-2 using th...

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Bibliographic Details
Main Authors: Karthik Siram, Stephanie K. Lathrop, Walid M. Abdelwahab, Rebekah Tee, Clara J. Davison, Haley A. Partlow, Jay T. Evans, David J. Burkhart
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Vaccines
Subjects:
toll-like receptor (TLR) agonist
TLR4
TLR7/8
adjuvants
alhydrogel
adju-phos
Online Access:https://www.mdpi.com/2076-393X/12/1/21

Internet

https://www.mdpi.com/2076-393X/12/1/21

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