Chloride Channel Blockers Suppress Formation of Engulfment Pseudopodia in Microglial Cells

Chloride Channel Blockers Suppress Formation of Engulfment Pseudopodia in Microglial Cells

Background/Aims: Phagocytosis depends on the formation of engulfment pseudopodia surrounding the target. We tested in microglia, monocyte-derived cells in the brain, whether a swelling-activated Cl--current (ICl,swell), required for global cell volume (CV) regulation, also contributes to local expan...

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Bibliographic Details
Main Authors: Barbara Harl, Judith Schmölzer, Martin Jakab, Markus Ritter, Hubert H. Kerschbaum
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cl > conductance
Hyperosmotic solution
Hypoosmotic solution
Microglial BV-2 cells
Primary microglial cells
Phagocytosis
Cell volume
Online Access:http://www.karger.com/Article/FullText/343370

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http://www.karger.com/Article/FullText/343370

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