Accumulation of STR-Loci Aberrations in Subclones of Jurkat Cell Line as a Model of Tumor Clonal Evolution

Accumulation of STR-Loci Aberrations in Subclones of Jurkat Cell Line as a Model of Tumor Clonal Evolution

Many genetic markers are known to distinguish tumor cells from normal. Genetic lesions found at disease onset often belong to a predominant tumor clone, and further observation makes it possible to assess the fate of this clone during therapy. However, minor clones escape monitoring and become unide...

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Bibliographic Details
Main Authors: Natalya Risinskaya, Olga Glinshchikova, Tatiana Makarik, Yana Kozhevnikova, Julia Chabaeva, Sergey Kulikov
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Genes
Subjects:
tumor clonal evolution
STR profiling
Jurkat subclones
WIL2-S subclones
loss of heterozygosity (LOH)
elevated microsatellite alteration at selected tetranucleotide repeats (EMAST)
Online Access:https://www.mdpi.com/2073-4425/14/3/571

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https://www.mdpi.com/2073-4425/14/3/571

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