Accumulation of STR-Loci Aberrations in Subclones of Jurkat Cell Line as a Model of Tumor Clonal Evolution

Accumulation of STR-Loci Aberrations in Subclones of Jurkat Cell Line as a Model of Tumor Clonal Evolution

Many genetic markers are known to distinguish tumor cells from normal. Genetic lesions found at disease onset often belong to a predominant tumor clone, and further observation makes it possible to assess the fate of this clone during therapy. However, minor clones escape monitoring and become unide...

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Bibliographic Details
Main Authors:	Natalya Risinskaya, Olga Glinshchikova, Tatiana Makarik, Yana Kozhevnikova, Julia Chabaeva, Sergey Kulikov
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Genes
Subjects:	tumor clonal evolution STR profiling Jurkat subclones WIL2-S subclones loss of heterozygosity (LOH) elevated microsatellite alteration at selected tetranucleotide repeats (EMAST)
Online Access:	https://www.mdpi.com/2073-4425/14/3/571

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