Notch Signaling Suppresses Melanoma Tumor Development in BRAF/Pten Mice

Notch Signaling Suppresses Melanoma Tumor Development in BRAF/Pten Mice

Both oncogenic and tumor suppressor roles have been assigned to Notch signaling in melanoma. In clinical trials, Notch inhibitors proved to be ineffective for melanoma treatment. Notch signaling has also been implicated in melanoma transdifferentiation, a prognostic feature in primary melanoma. In t...

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Bibliographic Details
Main Authors: Dareen Mikheil, Kirthana Prabhakar, Tun Lee Ng, Sireesh Teertam, B. Jack Longley, Michael A. Newton, Vijayasaradhi Setaluri
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
Notch signaling
melanoma
melanoma tumor development
melanoma TMA
melanoma mouse model
Online Access:https://www.mdpi.com/2072-6694/15/2/519

Internet

https://www.mdpi.com/2072-6694/15/2/519

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