Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling

Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling

Neonatal necrotizing enterocolitis (NEC) is an inflammatory disease that occurs in premature infants and has a high mortality rate; however, the mechanisms behind this disease remain unclear. The TLR4 signaling pathway in intestinal epithelial cells, mediated by TLR4, is important for the activation...

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Bibliographic Details
Main Authors: Dabin Huang, Ping Wang, Juncao Chen, Yanbin Li, Mingwei Zhu, Yaping Tang, Wei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
NEC
MD2
TLR4
NF-κB
intestinal barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.995791/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.995791/full

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