Translation of the 27-gene immuno-oncology test (IO score) to predict outcomes in immune checkpoint inhibitor treated metastatic urothelial cancer patients

Translation of the 27-gene immuno-oncology test (IO score) to predict outcomes in immune checkpoint inhibitor treated metastatic urothelial cancer patients

Abstract Background The IO Score is a 27-gene immuno-oncology (IO) classifier that has previously predicted benefit to immune checkpoint inhibitor (ICI) therapy in triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC). It generates both a continuous score and a binary result us...

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Bibliographic Details
Main Authors: Robert S. Seitz, Michael E. Hurwitz, Tyler J. Nielsen, Daniel B. Bailey, Matthew G. Varga, Brian Z. Ring, Carrie F. Metts, Brock L. Schweitzer, Kimberly McGregor, Douglas T. Ross
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Translational Medicine
Subjects:
Immuno-oncology
Immunotherapy
Biomarker
Tumor immune microenvironment
Bladder cancer
Metastatic urothelial cancer
Online Access:https://doi.org/10.1186/s12967-022-03563-9

Internet

https://doi.org/10.1186/s12967-022-03563-9

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