Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics

Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics

All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and thick filament proteins within the myocyte. The thin filament consists of the proteins actin, tropomyosin, Troponin C, Troponin I, and Troponin T. Mutations in these proteins can result in various forms of card...

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Bibliographic Details
Main Authors: Lucas K. Keyt, Jason M. Duran, Quan M. Bui, Chao Chen, Michael I. Miyamoto, Jorge Silva Enciso, Jil C. Tardiff, Eric D. Adler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
thin filament
cardiomyopathy
TNNI3
TNNT2
TNNC1
TPM1
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.972301/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.972301/full

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