Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern

Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern

Models based in differential expansion of elastic material, axonal constraints, directed growth, or multi-phasic combinations have been proposed to explain brain folding. However, the cellular and physical processes present during folding have not been defined. We used the murine cerebellum to chall...

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Bibliographic Details
Main Authors: Andrew K Lawton, Tyler Engstrom, Daniel Rohrbach, Masaaki Omura, Daniel H Turnbull, Jonathan Mamou, Teng Zhang, J M Schwarz, Alexandra L Joyner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
cerebellum
brain Folding
morphogenesis
multi-phase model
differential expansion
fluidity
Online Access:https://elifesciences.org/articles/45019

Internet

https://elifesciences.org/articles/45019

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