Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading

Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading

We have recently identified point mutation V336Y in mitoribosomal protein Mrps5 (uS5m) as a mitoribosomal <i>ram</i> (ribosomal ambiguity) mutation conferring error-prone mitochondrial protein synthesis. In vivo in transgenic knock-in animals, homologous mutation V338Y was associated wit...

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Bibliographic Details
Main Authors: Reda Juskeviciene, Ann-Kristina Fritz, Margarita Brilkova, Rashid Akbergenov, Karen Schmitt, Hubert Rehrauer, Endre Laczko, Patricia Isnard-Petit, Kader Thiam, Anne Eckert, Jochen Schacht, David P. Wolfer, Erik C. Böttger, Dimitri Shcherbakov
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
point mutation
mitoribosomal protein
misreading
mitochondria
protein synthesis
Online Access:https://www.mdpi.com/1422-0067/23/8/4384

Internet

https://www.mdpi.com/1422-0067/23/8/4384

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