Recombinant Listeria ivanovii strain expressing listeriolysin O in place of ivanolysin O might be a potential antigen carrier for vaccine construction

Recombinant Listeria ivanovii strain expressing listeriolysin O in place of ivanolysin O might be a potential antigen carrier for vaccine construction

Listeria monocytogenes (LM) induces efficient and specific T-cell immune responses in the host. Listeriolysin O (LLO) is the main virulence protein of LM. LLO helps LM escape from the lysosome. However, the pronounced pathogenicity of LM limits its practical application as a live bacterial vector. L...

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Bibliographic Details
Main Authors: Qian Liang, Ruidan Li, Sijing Liu, Yunwen Zhang, Sicheng Tian, Qian Ou, Zhaobin Chen, Chuan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Microbiology
Subjects:
Listeria monocytogenes
Listeria ivanovii
listeriolysin O
ivanolysin O
immune effect
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.962326/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.962326/full

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