Dapagliflozin prevents oxidative stress-induced endothelial dysfunction via sirtuin 1 activation

Dapagliflozin prevents oxidative stress-induced endothelial dysfunction via sirtuin 1 activation

Recent studies have demonstrated that dapagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, prevents endothelial dysfunction; however, direct effects of dapagliflozin on the endothelium under oxidative stress and the underlying mechanism of action are not completely understood. Thi...

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Bibliographic Details
Main Authors: Ying Zhou, Shi Tai, Ningjie Zhang, Liyao Fu, Yongjun Wang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Dapagliflozin
Endothelial cells
Oxidative stress
SIRT1
Senescence, SGLT2
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010041

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http://www.sciencedirect.com/science/article/pii/S0753332223010041

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