Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate

Hippo signaling plays an essential role in the development of numerous tissues. Although it was previously shown that the transcriptional effectors of Hippo signaling Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) can fine-tune the regulation of sex differe...

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Bibliographic Details
Main Authors: Nour Abou Nader, Amélie Ménard, Adrien Levasseur, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boyer
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
Hippo signaling
Lats1/2
fetal Leydig cells
Sertoli cells
transgenic mouse model
Online Access:https://www.mdpi.com/1422-0067/23/21/13585

Internet

https://www.mdpi.com/1422-0067/23/21/13585

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