Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation

Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation

Background and AimsActivation of the cAMP/Epac signalling stabilises endothelial barrier function. Moreover, its activation is accompanied by an activation of PI3K/Akt and MEK/ERK signalling in diverse cell types but their impact on endothelial barrier function is largely unknown. Here the role of P...

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Bibliographic Details
Main Authors: Dursun Gündüz, Christian Troidl, Christian Tanislav, Susanne Rohrbach, Christian Hamm, Muhammad Aslam
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Physiology
Subjects:
adherens junctions
Rac1
peripheral actin
cell survival
VE-cadherin
endothelial permeability
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01387/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01387/full

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