Mob2 Insufficiency Disrupts Neuronal Migration in the Developing Cortex

Mob2 Insufficiency Disrupts Neuronal Migration in the Developing Cortex

Disorders of neuronal mispositioning during brain development are phenotypically heterogeneous and their genetic causes remain largely unknown. Here, we report biallelic variants in a Hippo signaling factor—MOB2—in a patient with one such disorder, periventricular nodular heterotopia (PH). Genetic a...

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Bibliographic Details
Main Authors: Adam C. O’Neill, Christina Kyrousi, Melanie Einsiedler, Ingo Burtscher, Micha Drukker, David M. Markie, Edwin P. Kirk, Magdalena Götz, Stephen P. Robertson, Silvia Cappello
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Mob2
Hippo pathway
periventricular heterotopia
cortical development
exome sequencing
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00057/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00057/full

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