The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage

The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage

Abstract Background Renal fibrosis significantly contributes to the progressive loss of kidney function in chronic kidney disease (CKD), with alternatively activated M2 macrophages playing a crucial role in this progression. The serum succinate level is consistently elevated in individuals with diab...

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Bibliographic Details
Main Authors: Min Pu, Jing Zhang, Fuyan Hong, Yan Wang, Chengwei Zhang, Yongcheng Zeng, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Online Access:https://doi.org/10.1186/s12964-024-01481-5

Internet

https://doi.org/10.1186/s12964-024-01481-5

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