An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling

An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling

An integrated multi-omics analysis identifies an association chain among sleep-disordered breathing (SDB) traits, gene expression in circulating leukocytes, and serum metabolites, and supports a mechanistic role for P2XR4 purinergic signaling in SDB.

Bibliographic Details
Main Authors: Nuzulul Kurniansyah, Danielle A. Wallace, Ying Zhang, Bing Yu, Brian Cade, Heming Wang, Heather M. Ochs-Balcom, Alexander P. Reiner, Alberto R. Ramos, Joshua D. Smith, Jianwen Cai, Martha Daviglus, Phyllis C. Zee, Robert Kaplan, Charles Kooperberg, Stephen S. Rich, Jerome I. Rotter, Sina A. Gharib, Susan Redline, Tamar Sofer
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04520-y

Internet

https://doi.org/10.1038/s42003-023-04520-y

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