CCR5/CXCR4 Dual Antagonism for the Improvement of HIV Infection Therapy

CCR5/CXCR4 Dual Antagonism for the Improvement of HIV Infection Therapy

HIV entry in the host cell requires the interaction with the CD4 membrane receptor, and depends on the activation of one or both co-receptors CCR5 and CXCR4. Former selective co-receptor antagonists, acting at early stages of infection, are able to impair the receptor functions, preventing the viral...

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Bibliographic Details
Main Authors: Fedora Grande, Maria Antonietta Occhiuzzi, Bruno Rizzuti, Giuseppina Ioele, Michele De Luca, Paola Tucci, Valentina Svicher, Stefano Aquaro, Antonio Garofalo
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
chemokine receptors
dual drugs
HIV entry
AIDS
Online Access:https://www.mdpi.com/1420-3049/24/3/550

Internet

https://www.mdpi.com/1420-3049/24/3/550

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