Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion

Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion

A hallmark of ovarian high‐grade serous carcinoma (HGSC) is its early and massive peritoneal dissemination via the peritoneal fluid. It is generally believed that tumor cells must breach the mesothelium of peritoneal organs to adhere to the underlying extracellular matrix (ECM) and initiate metastat...

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Bibliographic Details
Main Authors: Kaire Ojasalu, Corinna Brehm, Kristin Hartung, Maximilian Nischak, Florian Finkernagel, Peter Rexin, Andrea Nist, Evangelos Pavlakis, Thorsten Stiewe, Julia M. Jansen, Uwe Wagner, Stefan Gattenlöhner, Andreas Bräuninger, Sabine Müller‐Brüsselbach, Silke Reinartz, Rolf Müller
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Molecular Oncology
Subjects:
adhesion
calretinin
driver mutations
mesothelial cells
metastasis
ovarian cancer
Online Access:https://doi.org/10.1002/1878-0261.12749

Internet

https://doi.org/10.1002/1878-0261.12749

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