EGCG Enhanced the Anti-tumor Effect of Doxorubicine in Bladder Cancer via NF-κB/MDM2/p53 Pathway

EGCG Enhanced the Anti-tumor Effect of Doxorubicine in Bladder Cancer via NF-κB/MDM2/p53 Pathway

Doxorubicin (DOX), the first-line chemotherapy for bladder cancer, usually induces side effects. We previously demonstrated that green tea polyphenol EGCG had potent anti-tumor effect in bladder cancer via down regulation of NF-κB. This study aimed to investigate the additive/synergistic effect EGCG...

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Bibliographic Details
Main Authors: Ke-Wang Luo, Xiao-hong Zhu, Ting Zhao, Jin Zhong, Han-chao Gao, Xin-Le Luo, Wei-Ren Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
MDM2
p53
NF-κB
bladder cancer
doxorubicine
EGCG
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.606123/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.606123/full

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